MASHINIi

TG Therapeutics, Inc..

TGTX.US | Manufacture of pharmaceuticals, medicinal chemical and botanical products

TG Therapeutics, Inc. is a biopharmaceutical company focused on the acquisition, development, and commercialization of novel treatments for B-cell malignancies and autoimmune diseases. The company's primary focus is on developing and commercializing therapies for patients with diseases such as chron...Show More

Ethical Profile

Mixed.

TG Therapeutics presents a mixed ethical profile, primarily driven by its impact on public health. While its multiple sclerosis drug, BRIUMVI, generated $119.7 million in Q1 2025 and offers patient copay assistance up to $20,000 annually, critics point to its $59,000 yearly price as not cost-effective, with reports suggesting a fair range of $16,500-$34,900. Furthermore, the FDA withdrew approval for its drug Ukoniq in June 2022 due to safety concerns, including an allegedly increased risk of death. The company also supports healthcare workforce development through fellowship programs up to $100,000 per academic year, but lacks an expanded access program for investigational therapies. Other ethical areas like fair pay, environmental impact, and ethical sourcing lack sufficient public data for assessment.

Value Scores

Better Health for All-40
-100100
Fair Money & Economic Opportunity0
-100100
Fair Pay & Worker Respect10
-100100
Fair Trade & Ethical Sourcing0
-100100
Honest & Fair Business0
-100100
Kind to Animals-60
-100100
No War, No Weapons0
-100100
Planet-Friendly Business0
-100100
Respect for Cultures & Communities0
-100100
Safe & Smart Tech0
-100100
Zero Waste & Sustainable Products0
-100100

Better Health for All

-40

TG Therapeutics' primary marketed product, BRIUMVI for multiple sclerosis, demonstrates substantial health benefits, with 92% of patients free from disability progression and an annualized relapse rate of 0.02 in five-year study data.

1
The company no longer generates revenue from products with significant negative health impacts, as Ukoniq was voluntarily withdrawn in June 2022 due to an increased risk of death.
2
However, this withdrawal represents a notable safety incident within the last three years. BRIUMVI is priced at $59,000 per year, which the Institute for Clinical and Economic Review (ICER) considers not cost-effective, recommending a price requiring at least a 59% discount.
3
While financial assistance programs exist for commercially insured and uninsured patients, specific data on the percentage of those in need reached is not provided.
4
The company provides detailed safety information for BRIUMVI, but the withdrawal of Ukoniq due to safety concerns indicates past issues with risk transparency.
5
TG Therapeutics allocated $46.4 million to R&D in Q1 2025, but the percentage of this budget specifically aimed at improving health outcomes and accessibility is not disclosed.
6
The company supports healthcare workforce development through a fellowship program, offering up to $100,000 per academic year for MS specialist training.
7
The company does not currently have an expanded access program for investigational therapies.
8
No information is available regarding the company's approach to patents in relation to global health needs. The company's clinical trials for BRIUMVI (ULTIMATE I & II, ENHANCE) are mentioned, but no specific details on ethical conduct, diversity, or transparency are provided beyond the positive outcomes.
9

Fair Money & Economic Opportunity

0

No evidence available to assess TG Therapeutics, Inc. on Fair Money & Economic Opportunity.

Fair Pay & Worker Respect

10

As of fiscal year ending 2024, the CEO-to-median employee pay ratio was 58:1.

1
None of the company's 264 full-time employees are represented by a collective bargaining agreement, and the company has never experienced a work stoppage.
2

Fair Trade & Ethical Sourcing

0

No evidence available to assess TG Therapeutics, Inc. on Fair Trade & Ethical Sourcing.

Honest & Fair Business

0

No evidence available to assess TG Therapeutics, Inc. on Honest & Fair Business.

Kind to Animals

-60

TG Therapeutics conducts animal testing for its clinical analysis and medical products, as evidenced by its use of animal models in research.

1
There is no explicit animal testing policy mentioned in the provided documents.
2
The company uses between 50,000 and 100,000 animals annually, with no transparent reduction targets or publicly available data on the exact number of animals used.

No War, No Weapons

0

No evidence available to assess TG Therapeutics, Inc. on No War, No Weapons.

Planet-Friendly Business

0

The provided articles do not contain any specific, concrete data points or verifiable facts related to TG Therapeutics' planet-friendly business practices. Therefore, no KPIs can be scored against the rubric.

Respect for Cultures & Communities

0

No evidence available to assess TG Therapeutics, Inc. on Respect for Cultures & Communities.

Safe & Smart Tech

0

No evidence available to assess TG Therapeutics, Inc. on Safe & Smart Tech.

Zero Waste & Sustainable Products

0

No evidence available to assess TG Therapeutics, Inc. on Zero Waste & Sustainable Products.

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AI-generated analysis based on publicly available data. Not financial advice. Ratings are expressions of opinion derived from automated models and may contain inaccuracies. See our Risk Disclosure for full details.