Silence Therapeutics Plc.
SLN.US | Research and experimental development on natural sciences and engineering
Silence Therapeutics Plc is a biotechnology company focused on the discovery and development of novel ribonucleic acid interference (RNAi) therapeutics. The company's primary focus is on developing medicines by harnessing the body's natural mechanisms to silence disease-causing genes. Silence Therap...Show More
Better Health for All
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Silence Therapeutics' core business is developing precision-engineered RNAi therapeutics to silence disease-causing genes, aiming to transform lives by addressing unmet medical needs. Their lead candidate, Zerlasiran (SLN360), demonstrated a median percentage reduction in Lipoprotein(a) (Lp(a)) of 90% or greater in a Phase 2 study (ALPACAR-360) at week 36.
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High Lp(a) is a genetic risk factor for atherosclerotic cardiovascular disease (ASCVD), affecting up to 20% of the world's population, or approximately 1.4 billion people globally.
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The company has no revenue from products with negative health impacts, as all offerings are investigational therapies designed for health improvement. No new safety concerns were identified during the 36-week treatment period of the ALPACAR-360 study.
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The company focuses on patients with limited or inadequate treatment options and is developing SLN360 as a potential long-term preventative treatment.
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Silence Therapeutics pioneers in siRNA design and development, utilizing its proprietary mRNAi GOLD™ platform, and maintains R&D collaborations with partners like AstraZeneca and Hansoh Pharma.
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The company promises to treat data with respect and not share information with any third party.
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Silence conducts clinical trials to the highest standards of safety and ethics, with more information available on clinicaltrials.gov.
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Fair Money & Economic Opportunity
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No evidence available to assess Silence Therapeutics Plc on Fair Money & Economic Opportunity.
Fair Pay & Worker Respect
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No evidence available to assess Silence Therapeutics Plc on Fair Pay & Worker Respect.
Fair Trade & Ethical Sourcing
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No evidence available to assess Silence Therapeutics Plc on Fair Trade & Ethical Sourcing.
Honest & Fair Business
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No evidence available to assess Silence Therapeutics Plc on Honest & Fair Business.
Kind to Animals
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The company uses in silico algorithms and in vitro screening for early-stage identification of siRNAs, but top candidates are subsequently tested for safety and efficacy in animal models.
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Non-human primate studies are required for drug candidate selection for clinical trials.
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The company explicitly states it uses animals for product testing, and there is no evidence of a policy to reduce or phase out animal testing.
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No War, No Weapons
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Silence Therapeutics Plc is a biotechnology company focused on RNAi therapeutics. The provided articles consistently state that the company's activities are not applicable to the arms or defense industry, nor to peacebuilding or conflict-related sectors. Therefore, all KPIs related to arms contracts, dual-use technology, sales to embargoed regimes, peacebuilding investment, conflict divestment, defense oversight, export controls, lobbying on arms control, humanitarian procurement, human rights due diligence in conflict areas, Arms Trade Treaty compliance, AI military safeguards, UN Guiding Principles alignment, dual-use screening, surveillance, ethical red lines, controversial weapons exposure, war-risk audits, conflict partner reviews, defense divestment, conflict minerals, peace tech investment, and conflict zone procurement are marked as N/A, indicating no involvement in these areas.
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Planet-Friendly Business
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No evidence available to assess Silence Therapeutics Plc on Planet-Friendly Business.
Respect for Cultures & Communities
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No specific, concrete data points were found in the provided articles for any of the KPIs related to 'Respect for Cultures & Communities'. The articles primarily focus on financial performance, clinical trials, and general corporate conduct, without detailing engagement with local or indigenous communities, cultural impact assessments, or specific charitable giving to cultural heritage organizations.
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Safe & Smart Tech
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The company has no documented data breaches or incidents of unauthorized data use.
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It acknowledges being subject to stringent and evolving data privacy and security laws and regulations, and states that failure to comply could lead to regulatory actions, fines, and penalties.
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The company mentions a 'Privacy and Cookie Notice' and the ability for users to unsubscribe from investor alerts, indicating basic data control options.
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However, there is no evidence of specific compliance programs, certifications, or regulatory penalties.
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Zero Waste & Sustainable Products
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Silence Therapeutics has issued company recommendations to reduce individual employee’s environmental impact and promote better work-from-home practices.
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The company's operations involve hazardous materials and waste, and it is subject to numerous environmental, health, and safety laws and regulations governing their handling, use, storage, treatment, and disposal.
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The company and its contract manufacturers are also subject to periodic inspections by regulatory authorities to ensure compliance with cGMP.
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