Kezar Life Sciences, Inc..
KZR.US | Manufacture of pharmaceuticals, medicinal chemical and botanical products
Kezar Life Sciences, Inc. is a clinical-stage biotechnology company discovering and developing novel treatments for immune-mediated diseases and cancer. The company focuses on small molecule therapeutics that harness protein homeostasis to address unmet needs. Their lead product candidate, zetomipzo...Show More
Better Health for All
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Kezar Life Sciences is a clinical-stage biotechnology company developing treatments for immune-mediated diseases and cancer. Its lead product candidate, zetomipzomib, has shown mixed results. The Phase 2 MISSION trial for lupus nephritis reported 64.7% of 69 patients achieved the primary efficacy endpoint.
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The PORTOLA trial for autoimmune hepatitis had a positive IDMC safety review with no Grade 4 or 5 serious adverse events (SAEs) among 24 patients.
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However, the PALIZADE trial for lupus nephritis was terminated due to 4 Grade 5 (fatal) SAEs among 84 enrolled patients, leading to a clinical hold by the FDA.
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Another drug, KZR-261 for solid tumors, was halted after showing no objective responses in 61 patients, though 5 had stable disease for 4+ months and 2 for 1+ year.
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The company alerted regulatory agencies about the PALIZADE study pause and the FDA issued a clinical hold.
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Kezar's R&D expenses were $16.3 million in Q2 2024, down from $21.0 million in Q2 2023, and the company underwent a 41% workforce reduction in October 2023, halting all preclinical programs.
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Fair Money & Economic Opportunity
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Kezar Life Sciences, Inc. is a clinical-stage biotechnology company focused on discovering and developing novel treatments for diseases. The company does not offer lending, deposit, or other financial services to consumers.
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Therefore, all KPIs related to fair money and economic opportunity, which are designed for financial institutions, are not applicable to its core business operations.
Fair Pay & Worker Respect
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No specific, quantitative data was provided in the articles to assess Kezar Life Sciences against the KPIs for Fair Pay & Worker Respect. Information regarding living wage coverage, CEO-median pay ratio, collective bargaining share, safety incident rate, pay equity ratio, worker engagement score, turnover rate, labor violation incidents, insecure contract share, or health insurance coverage percentage was not available.
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Fair Trade & Ethical Sourcing
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No evidence available to assess Kezar Life Sciences, Inc. on Fair Trade & Ethical Sourcing.
Honest & Fair Business
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Kezar Life Sciences, Inc. provides a confidential and anonymous financial concern hotline, along with a secure web form for complaints related to accounting, internal accounting controls, or auditing matters.
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The company's Audit Committee is responsible for receiving and treating these complaints.
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This facility is a requirement mandated by the SEC.
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Kind to Animals
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No evidence available to assess Kezar Life Sciences, Inc. on Kind to Animals.
No War, No Weapons
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The provided articles for Kezar Life Sciences, Inc. do not contain any specific, concrete data points or facts relevant to the 'No War, No Weapons' ethical value or any of its associated KPIs.
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Both articles explicitly state that the categories are 'Not Applicable' or that 'no information' is available.
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Therefore, no KPIs can be scored based on the evidence provided.
Planet-Friendly Business
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No evidence available to assess Kezar Life Sciences, Inc. on Planet-Friendly Business.
Respect for Cultures & Communities
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No evidence available to assess Kezar Life Sciences, Inc. on Respect for Cultures & Communities.
Safe & Smart Tech
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No evidence available to assess Kezar Life Sciences, Inc. on Safe & Smart Tech.
Zero Waste & Sustainable Products
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No evidence available to assess Kezar Life Sciences, Inc. on Zero Waste & Sustainable Products.